The following directory lists the graduate courses which the University expects to offer, although the University in no way guarantees that all such courses will be offered in any given academic year, and reserves the right to alter the list if conditions warrant. Click on the links below for a list of courses in that subject area. You may then click “View Classes” to see scheduled classes for individual courses.
5150. Dynamical Modeling of Biochemical Networks
Grading Basis: Graded
Recent advances in biological measurement technology have opened up a new era in quantitative biology. Part of this revolution is the new field of systems biology, which consists of viewing processes in biological cells as a whole, rather than considering one gene or protein at a time. Systems biology relies heavily on mathematical models of cellular processes, often derived from the microscopic laws of chemical and enzyme kinetics. Focus primarily on continuum (differential equation) models of cellular processes arising from these microscopic laws. Because most of these models wind up being nonlinear, time is devoted to learning techniques to analyze systems of nonlinear ordinary differential equations, and we will explore the fundamental differences between linear and nonlinear systems. Biological applications will include modeling observed error rates in protein translation, using system nonlinearities to design biological toggle switches, and exploring biological motifs that lead to oscillations, switches, and other behaviors.
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